chlorzoxazone

klor-ZOX-a-zone

Commonly used brand name(s)

In the U.S.

• Lorzone


• Parafon Forte DSC


• Remular-S

Available Dosage Forms:

• Capsule


• Tablet

Therapeutic Class: Skeletal Muscle Relaxant, Centrally Acting

Uses For chlorzoxazone

Chlorzoxazone is used to relax certain muscles in your body and relieve the discomfort caused by acute (short-term), painful muscle or bone conditions. However, chlorzoxazone does not take the place of rest, exercise, physical therapy, or other treatments that your doctor may recommend for your medical condition.

Chlorzoxazone is a skeletal muscle relaxant. It acts on the central nervous system (CNS) to relax muscles.

chlorzoxazone is available only with your doctor's prescription.

Before Using chlorzoxazone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For chlorzoxazone, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to chlorzoxazone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

No information is available on the relationship of age to the effects of chlorzoxazone in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of chlorzoxazone in geriatric patients. However, elderly patients are more likely to have age-related liver problems, which may require caution in patients receiving chlorzoxazone.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking chlorzoxazone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using chlorzoxazone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Adinazolam


• Alfentanil


• Alprazolam


• Amobarbital


• Anileridine


• Aprobarbital


• Bromazepam


• Brotizolam


• Butabarbital


• Butalbital


• Carisoprodol


• Chloral Hydrate


• Chlordiazepoxide


• Chlorzoxazone


• Clobazam


• Clonazepam


• Clorazepate


• Codeine


• Dantrolene


• Diazepam


• Estazolam


• Ethchlorvynol


• Fentanyl


• Flunitrazepam


• Flurazepam


• Halazepam


• Hydrocodone


• Hydromorphone


• Ketazolam


• Levorphanol


• Lorazepam


• Lormetazepam


• Medazepam


• Meperidine


• Mephenesin


• Mephobarbital


• Meprobamate


• Metaxalone


• Methocarbamol


• Methohexital


• Midazolam


• Morphine


• Morphine Sulfate Liposome


• Nitrazepam


• Nordazepam


• Oxazepam


• Oxycodone


• Oxymorphone


• Pentobarbital


• Phenobarbital


• Prazepam


• Primidone


• Propoxyphene


• Quazepam


• Remifentanil


• Secobarbital


• Sodium Oxybate


• Sufentanil


• Temazepam


• Thiopental


• Triazolam

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of chlorzoxazone. Make sure you tell your doctor if you have any other medical problems, especially:

• Liver disease—Use with caution. May increase the risk of serious side effects.

Proper Use of chlorzoxazone

Dosing

The dose of chlorzoxazone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of chlorzoxazone. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For relaxing muscles:
    
    • Adults—500 milligrams (mg) three or four times a day. Your doctor may adjust your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of chlorzoxazone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using chlorzoxazone

It is very important that your doctor check your progress at regular visits to make sure that chlorzoxazone is working properly and to check for unwanted effects.

Liver problems may occur while you are using chlorzoxazone. Stop using chlorzoxazone and check with your doctor right away if you are having more than one of these symptoms: abdominal pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; itching; loss of appetite; nausea and vomiting; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.

chlorzoxazone will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; or anesthetics, including some dental anesthetics. Check with your medical doctor or dentist before taking any of these medicines while you are taking chlorzoxazone.

chlorzoxazone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

• Bloody or black, tarry stools


• clay-colored stools


• constipation


• cough


• dark urine


• decreased appetite


• difficulty swallowing


• dizziness


• fast heartbeat


• fever


• headache


• hives


• itching


• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• loss of appetite


• nausea and vomiting


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• severe stomach pain


• shortness of breath


• skin rash


• swelling of the feet or lower legs


• tightness in the chest


• unusual tiredness or weakness


• vomiting of blood or material that looks like coffee grounds


• wheezing


• yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Diarrhea


• difficult or troubled breathing


• drowsiness


• general feeling of discomfort or illness


• headache


• irregular, fast or slow, or shallow breathing


• lightheadedness


• nausea


• pale or blue lips, fingernails, or skin


• sluggishness


• vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

• Bruising


• large, flat, blue, or purplish patches in the skin


• small red or purple spots on the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: chlorzoxazone side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More chlorzoxazone resources

• Chlorzoxazone Side Effects (in more detail)
• Chlorzoxazone Use in Pregnancy & Breastfeeding
• Drug Images
• Chlorzoxazone Drug Interactions
• Chlorzoxazone Support Group
• 10 Reviews for Chlorzoxazone - Add your own review/rating

• chlorzoxazone Concise Consumer Information (Cerner Multum)


• Chlorzoxazone Prescribing Information (FDA)


• Chlorzoxazone Monograph (AHFS DI)


• Chlorzoxazone Professional Patient Advice (Wolters Kluwer)


• Chlorzoxazone MedFacts Consumer Leaflet (Wolters Kluwer)


• Parafon Forte DSC Prescribing Information (FDA)

Compare chlorzoxazone with other medications

• Muscle Spasm

Clindamycin Foam

Pronunciation: KLIN-da-MYE-sin
Generic Name: Clindamycin
Brand Name: Evoclin

Clindamycin Foam is used for:

Treating acne. It may also be used for other conditions as determined by your doctor.

Clindamycin Foam is a topical lincomycin antibiotic. It works by killing sensitive bacteria that cause acne and reducing the amount of free fatty acids that irritate the skin surface.

Do NOT use Clindamycin Foam if:

• you are allergic to any ingredient in Clindamycin Foam or to lincomycin


• you have Crohn disease or a history of severe bowel problems (eg, regional enteritis), colitis associated with antibiotic use, or ulcerative colitis

Contact your doctor or health care provider right away if any of these apply to you.

Before using Clindamycin Foam:

Some medical conditions may interact with Clindamycin Foam. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have gastrointestinal (bowel) disease or diarrhea

Some MEDICINES MAY INTERACT with Clindamycin Foam. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Nondepolarizing muscle relaxants (eg, vecuronium) or succinylcholine because their actions and the risk of their side effects may be increased by Clindamycin Foam


• Erythromycin because it may decrease Clindamycin Foam's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Clindamycin Foam may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Clindamycin Foam:

Use Clindamycin Foam as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Clindamycin Foam is for topical use on the skin only.


• Wash the affected areas to be treated with mild soap and water and allow the skin to dry thoroughly.


• To use Clindamycin Foam, hold the can upright and dispense the amount of medicine to be used directly into the cap or onto a cool surface. Pick up small amounts of the foam with your fingertips and gently massage it into the affected areas until the foam disappears.


• If the can seems warm or the foam seems runny, hold the can under cold running water to cool it. Do not dispense the medicine directly onto your skin or hands because it will melt too soon.


• Throw away any unused medicine that has been dispensed out of the can.


• If you miss a dose of Clindamycin Foam, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Clindamycin Foam.

Important safety information:

• Clindamycin Foam is for external use only. Do not get Clindamycin Foam in your eyes or on the inside of your nose or mouth. If you accidentally get the medicine in your eye, immediately flush with a large amount of cool tap water.


• Be sure to use Clindamycin Foam for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.


• Several weeks may pass before you see improvement in your acne. Continue using Clindamycin Foam for the full time recommended by your doctor.


• Talk with your doctor before you use any other medicines or cleansers on your skin.


• If severe diarrhea, stomach pain or cramping, or bloody stools develop during treatment or within several months after treatment with Clindamycin Foam, check with your doctor or pharmacist right away. Do not treat it without first checking with your doctor.


• Clindamycin Foam should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: It is not known if Clindamycin Foam can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Clindamycin Foam while you are pregnant. It is not known if Clindamycin Foam is found in breast milk. Do not breast-feed while taking Clindamycin Foam.

Possible side effects of Clindamycin Foam:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Burning sensation on treated areas; dry or itchy skin; headache.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood or mucus in stools; severe or persistent diarrhea; stomach cramps or pain; swelling, redness, burning, or peeling of your skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Clindamycin Foam may be harmful if swallowed.

Proper storage of Clindamycin Foam:

Store Clindamycin Foam at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Store away from heat and direct sunlight. Do not puncture, break, or burn the canister even if it appears to be empty. Keep Clindamycin Foam out of the reach of children and away from pets.

General information:

• If you have any questions about Clindamycin Foam, please talk with your doctor, pharmacist, or other health care provider.


• Clindamycin Foam is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Clindamycin Foam. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Clindamycin resources

• Clindamycin Use in Pregnancy & Breastfeeding
• Clindamycin Drug Interactions
• Clindamycin Support Group
• 20 Reviews for Clindamycin - Add your own review/rating

Compare Clindamycin with other medications

• Acne
• Bacterial Vaginitis
• Perioral Dermatitis

Cipro IV

Generic Name: ciprofloxacin (Intravenous route)

sip-roe-FLOX-a-sin

Intravenous route(Solution)

Fluoroquinolones, including ciprofloxacin, are associated with an increased risk of tendinitis and tendon rupture in all ages. Risk further increases with age over 60 years, concomitant steroid therapy, and kidney, heart, or lung transplants. Fluoroquinolones, including ciprofloxacin, may exacerbate muscle weakness in persons with myasthenia gravis. Avoid in patients with known history of myasthenia gravis .

Commonly used brand name(s)

In the U.S.

• Cipro IV

In Canada

• Ciprofloxacin


• Cipro Iv Minibags

Available Dosage Forms:

• Solution

Therapeutic Class: Antibiotic

Chemical Class: Fluoroquinolone

Uses For Cipro IV

Ciprofloxacin injection is used to treat bacterial infections in many different parts of the body. It is also used to treat anthrax infection after inhalational exposure.

Ciprofloxacin belongs to the class of drugs known as fluoroquinolone antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Before Using Cipro IV

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ciprofloxacin injection in children. However, because of this medicine's toxicity, it should be used with caution, after other alternatives have been considered and/or found ineffective. Ciprofloxacin injection may be used in children to prevent anthrax infection after possible exposure, and to treat serious kidney infections.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ciprofloxacin injection in the elderly. However, elderly patients are more likely to have age-related heart or kidney problems, or develop severe tendon problems (including tendon rupture), which may require caution in patients receiving ciprofloxacin injection.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Cisapride


• Dronedarone


• Mesoridazine


• Pimozide


• Sparfloxacin


• Thioridazine


• Tizanidine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acarbose


• Acecainide


• Acetohexamide


• Alfuzosin


• Alosetron


• Amiodarone


• Amitriptyline


• Amoxapine


• Apomorphine


• Arsenic Trioxide


• Asenapine


• Astemizole


• Azimilide


• Azithromycin


• Bendamustine


• Benfluorex


• Bretylium


• Chlorpromazine


• Chlorpropamide


• Citalopram


• Clarithromycin


• Clomipramine


• Crizotinib


• Dasatinib


• Desipramine


• Disopyramide


• Dofetilide


• Dolasetron


• Droperidol


• Eltrombopag


• Erythromycin


• Flecainide


• Fluconazole


• Gatifloxacin


• Gemifloxacin


• Gliclazide


• Glimepiride


• Glipizide


• Gliquidone


• Glyburide


• Granisetron


• Guar Gum


• Halofantrine


• Haloperidol


• Ibutilide


• Iloperidone


• Imipramine


• Insulin


• Insulin Aspart, Recombinant


• Insulin Glulisine


• Insulin Lispro, Recombinant


• Lapatinib


• Levofloxacin


• Lopinavir


• Lumefantrine


• Mefloquine


• Metformin


• Methadone


• Miglitol


• Moricizine


• Moxifloxacin


• Nilotinib


• Norfloxacin


• Nortriptyline


• Octreotide


• Ofloxacin


• Ondansetron


• Paliperidone


• Pazopanib


• Perflutren Lipid Microsphere


• Posaconazole


• Procainamide


• Prochlorperazine


• Promethazine


• Propafenone


• Protriptyline


• Quetiapine


• Quinidine


• Quinine


• Ranolazine


• Salmeterol


• Saquinavir


• Sematilide


• Simvastatin


• Sodium Phosphate


• Sodium Phosphate, Dibasic


• Sodium Phosphate, Monobasic


• Solifenacin


• Sorafenib


• Sotalol


• Sunitinib


• Tedisamil


• Telavancin


• Telithromycin


• Terfenadine


• Tetrabenazine


• Theophylline


• Tolazamide


• Tolbutamide


• Toremifene


• Trazodone


• Trifluoperazine


• Trimipramine


• Troglitazone


• Vandetanib


• Vardenafil


• Vemurafenib


• Voriconazole


• Ziprasidone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Betamethasone


• Chloroquine


• Clozapine


• Corticotropin


• Cortisone


• Cosyntropin


• Cyclosporine


• Deflazacort


• Dexamethasone


• Diclofenac


• Dutasteride


• Erlotinib


• Fludrocortisone


• Fluocortolone


• Fosphenytoin


• Hydrocortisone


• Itraconazole


• Methylprednisolone


• Mycophenolate Mofetil


• Olanzapine


• Paramethasone


• Phenytoin


• Prednisolone


• Prednisone


• Probenecid


• Rasagiline


• Rifapentine


• Ropinirole


• Ropivacaine


• Sildenafil


• Triamcinolone


• Warfarin


• Zolpidem

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Caffeine

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Brain or spinal cord disease, including hardening of the arteries in the brain or epilepsy or other seizures or


• Diabetes or


• Diarrhea or


• Heart rhythm problems (e.g., prolonged QT interval) or


• Hypokalemia (low potassium in the blood), uncorrected—Use with caution. May make these conditions worse.

• Kidney disease—Use with caution. The effects may be increased because of slower removal of this medicine from the body.

• Myasthenia gravis (severe muscle weakness)—Should not be used in patients with this condition.

• Organ transplant (e.g., kidney, heart, or lung) or


• Tendon disorder (e.g., rheumatoid arthritis), history of—Use with caution. May increase the risk of tendon problems.

Proper Use of ciprofloxacin

This section provides information on the proper use of a number of products that contain ciprofloxacin. It may not be specific to Cipro IV. Please read with care.

A nurse or other trained health professional will give you or your child this medicine. This medicine is given through a needle placed in one of your veins. This medicine is given slowly, so the needle will remain in place for about an hour.

Drink extra fluids so you will pass more urine while you are using this medicine. This will keep your kidneys working well and help prevent kidney problems.

Your doctor will give you or your child a few doses of this medicine until your condition improves, and then you or your child may be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

This medicine comes with a Medication Guide. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

Precautions While Using Cipro IV

If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

Do not take tizanidine (Zanaflex®) while you are receiving this medicine. Tell your doctor if you or your child are also using theophylline (Theo-Dur®) or other products that contain caffeine (e.g., coffee, soda, chocolate). Using these medicines together may increase risks for more serious side effects.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you or your child have a rash; itching; hives; hoarseness; shortness of breath; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after you receive this medicine.

Serious skin reactions can occur with this medicine. Stop using this medicine and check with your doctor right away if you have blistering, peeling, or loosening of the skin; red skin lesions; severe acne or skin rash; sores or ulcers on the skin; or fever or chills while you or your child are using this medicine.

Stop using this medicine and check with your doctor right away if you or your child have dark urine, clay-colored stools, abdominal or stomach pain, or yellow eyes or skin. These maybe symptoms of a serious liver problem.

Some people who receive ciprofloxacin injection may become more sensitive to sunlight than they are normally. Exposure to sunlight, even for brief periods of time, may cause severe sunburn, or skin rash, redness, itching, or discoloration. When you or your child begin receiving this medicine:

• Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.


• Wear protective clothing, including a hat and sunglasses.


• Apply a sun block product that has a skin protection factor (SPF) of at least 15. Some people may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your doctor.


• Do not use a sunlamp or tanning bed or booth.

If you have a severe reaction from the sun, check with your doctor.

Ciprofloxacin injection may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that can be dangerous if you are dizzy or not alert. If these reactions are especially bothersome, check with your doctor.

Ciprofloxacin injection may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Tell your doctor right away if you or your child start having numbness, tingling, or burning pain in your hands, arms, legs, or feet. These may be symptoms of a condition called peripheral neuropathy.

This medicine can cause changes in heart rhythms, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats.

Ciprofloxacin may rarely cause inflammation or tearing of a tendon (the cord that attaches muscles to bones). This can occur while you are using the medicine or after you finish using it. The risk of having tendon problems may be increased if you are over 60 years of age, are using steroid medicines (e.g., dexamethasone, prednisolone, prednisone, or Medrol®), have severe kidney problems, have a history of tendon problems (e.g., rheumatoid arthritis), or if you have received an organ transplant (e.g., heart, kidney, or lung). Stop using this medicine and check with your doctor right away if you have sudden pain or swelling in a tendon after exercise (e.g., ankle, back of the knee or leg, shoulder, elbow, or wrist), bruise more easily after an injury, or are unable to bear weight or move the affected area. Refrain from exercise until your doctor says otherwise.

For diabetic patients taking diabetes medicine by mouth: Ciprofloxacin may cause hypoglycemia (low blood sugar) in some patients. Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). Different people may feel different symptoms of low blood sugar. If you or your child experience symptoms of low blood sugar, stop taking levofloxacin and check with your doctor right away:

• Symptoms of low blood sugar can include: Anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty with concentrating, drowsiness, excessive hunger, headache, nausea, nervousness, rapid heartbeat, shakiness, or unusual tiredness or weakness.

Cipro IV Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

• Black, tarry stools


• bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site


• chest pain


• chills


• cough


• fever


• painful or difficult urination


• rash


• shortness of breath


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• swollen glands


• unusual bleeding or bruising


• unusual tiredness or weakness

Rare

• Abdominal or stomach cramps or pain


• abdominal or stomach tenderness


• actions that are out of control


• aggressive and violent behavior


• ankle, knee, or great toe joint pain


• arm, back, or jaw pain


• back or side pain


• blistering, peeling, or loosening of the skin


• blisters under the skin


• bloating


• bloody or cloudy urine


• blue lips and fingernails


• blurred vision


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• change in walking and balance


• changes in skin color, pain, tenderness, or swelling of the foot or leg


• chest tightness or heaviness


• clay-colored stools


• clumsiness or unsteadiness


• cold, clammy, or pale skin


• constipation


• convulsions


• cough or hoarseness


• coughing or spitting up blood


• coughing that sometimes produces a pink frothy sputum


• cracks in the skin


• darkening of the skin


• decreased frequency or amount of urine


• delusions of persecution, mistrust, suspiciousness, or combativeness


• diarrhea, watery and severe, which may also be bloody


• difficult or labored breathing


• difficult, fast, noisy breathing, sometimes with wheezing


• difficulty in passing urine (dribbling)


• difficulty with breathing, chewing, swallowing, or talking


• difficulty with moving


• discouragement


• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


• double vision


• drooping eyelids


• drowsiness


• fainting


• fast, slow, irregular, pounding, or racing heartbeat or pulse


• fear or nervousness


• feeling of unreality


• feeling of warmth or heat


• feeling sad or empty


• fever with or without chills


• flushing or redness of the skin, especially on the face and neck


• frequent urination


• general feeling of tiredness or weakness


• greatly decreased frequency of urination or amount of urine


• groin pain


• headache, severe and throbbing


• heart stops


• hives or welts


• increased perspiration


• increased sensitivity of the skin to sunlight


• increased sweating


• increased thirst


• increased volume of pale, dilute urine


• indigestion


• irregular heartbeats


• irritability


• itching of the vagina or genital area


• itching skin


• joint or muscle pain


• joint stiffness or swelling


• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• light-colored stools


• loss of ability to use or understand speech or language


• loss of appetite


• loss of bladder control


• loss of heat from the body


• loss of interest or pleasure


• lower abdominal or stomach cramping


• lower back or side pain


• mood or mental changes


• muscle pain or stiffness


• muscle spasm or jerking of all extremities


• muscle weakness


• nausea and vomiting


• nightmares


• no breathing


• no pulse or blood pressure


• noisy breathing


• numbness of hands


• pain


• pain during sexual intercourse


• pain in the ankles or knees


• pain or discomfort in the arms, jaw, back, or neck


• painful oral mucosa


• painful, red lumps under the skin, mostly on the legs


• pains in the stomach, side, or abdomen, possibly radiating to the back


• pale skin


• pinpoint red or purple spots on the skin


• pounding in the ears


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• red skin lesions, often with a purple center


• red, irritated eyes


• red, swollen skin


• redness of the face, neck, arms, and occasionally, upper chest


• redness or other discoloration of the skin


• scaly skin


• seeing, hearing, or feeling things that are not there


• sense of detachment from self or body


• severe constipation


• severe sunburn


• severe tiredness


• severe vomiting


• shakiness and unsteady walk


• shakiness in the legs, arms, hands, or feet


• sleeplessness


• slow or irregular breathing


• small red or purple spots on the skin


• sores, welting, or blisters


• sudden decrease in the amount of urine


• sudden loss of consciousness


• sudden shortness of breath or troubled breathing


• sweating


• swelling of the lips, face, neck, eyes, hands, or lower extremities


• swelling of the lymph nodes


• talking, feeling, and acting with excitement


• thick, white vaginal discharge with no odor or with a mild odor


• tightness in the chest


• tiredness


• trouble concentrating


• trouble sleeping


• troubled breathing


• unable to sleep


• unpleasant breath odor


• unresponsiveness


• unsteadiness, trembling, or other problems with muscle control or coordination


• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness


• unusual weight gain


• unusual weight loss


• upper right abdominal pain


• vomiting of blood


• weakness


• weight gain


• wheezing


• yellow eyes and skin

Incidence not known

• Bleeding and bruising


• bleeding gums


• bluish-colored lips, fingernails, or palms


• bone pain


• confusion as to time, place, or person


• excessive muscle tone


• feeling of discomfort


• general body swelling


• high fever


• holding false beliefs that cannot be changed by fact


• increased sensitivity to pain or touch


• inflammation of the joints


• muscle aches


• muscle tension or tightness


• muscle twitching or jerking


• nosebleeds


• pain, inflammation, or swelling in the calves, shoulders, or hands


• painful, swollen joints


• rhythmic movement of muscles


• stomach pain, continuing


• swollen glands


• uncontrolled eye movements


• unexplained bleeding or bruising


• unsteadiness or awkwardness


• unusual excitement, nervousness, or restlessness


• weakness in the arms, hands, legs, or feet


• weakness or heaviness of the legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Acid or sour stomach


• belching


• heartburn


• runny nose


• sneezing


• stomach discomfort, upset, or pain


• stuffy nose

Rare

• Changes in vision


• continuing ringing or buzzing or other unexplained noise in the ears


• decreased vision


• dry mouth


• excess air or gas in the stomach or intestines


• eye pain


• full feeling


• hearing loss


• hiccup


• loss of sense of smell


• overbright appearance of lights


• passing gas


• seeing double


• seeing shades of colors differently than before


• sore mouth or tongue


• swelling of the breasts or breast soreness in both females and males


• white patches in the mouth and/or on the tongue

Incidence not known

• Hyperventilation


• loss of taste

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Cipro IV resources

• Cipro IV Use in Pregnancy & Breastfeeding
• Drug Images
• Cipro IV Drug Interactions
• Cipro IV Support Group
• 89 Reviews for Cipro IV - Add your own review/rating

Compare Cipro IV with other medications

• Anthrax
• Anthrax Prophylaxis
• Bacteremia
• Bacterial Infection
• Bladder Infection
• Bone infection
• Bronchitis
• Chancroid
• Cholera
• Crohn's Disease
• Cutaneous Bacillus anthracis
• Diverticulitis
• Epididymitis, Sexually Transmitted
• Febrile Neutropenia
• Gonococcal Infection, Disseminated
• Gonococcal Infection, Uncomplicated
• Granuloma Inguinale
• Infection Prophylaxis
• Infectious Diarrhea
• Intraabdominal Infection
• Joint Infection
• Kidney Infections
• Meningococcal Meningitis Prophylaxis
• Mycobacterium avium-intracellulare, Treatment
• Nosocomial Pneumonia
• Peritonitis
• Plague
• Pneumonia
• Pneumonia with Cystic Fibrosis
• Prostatitis
• Rabbit Fever
• Salmonella Enteric Fever
• Salmonella Gastroenteritis
• Shigellosis
• Sinusitis
• Skin Infection
• Traveler's Diarrhea
• Tuberculosis, Active
• Typhoid Fever
• Urinary Tract Infection

Nansen

Nansen may be available in the countries listed below.

Ingredient matches for Nansen

Omeprazole

Omeprazole is reported as an ingredient of Nansen in the following countries:

• Italy

International Drug Name Search

EndaCof DH

dihydrocodeine bitartrate, brompheniramine maleate and phenylephrine hydrochloride

Dosage Form: liquid
Cv

ENDACOF-DH

Oral Liquid

Rx Only

EndaCof DH Description

Each 5 mL (one teaspoonful) for oral administration contains:

* (WARNING-May be habit forming)
Dihydrocodeine Bitartrate*	3 mg
Brompheniramine Maleate	4 mg
Phenylephrine Hydrochloride	7.5 mg

ENDACOF-DH Oral Liquid also contains: Sodium benzoate, Citric acid, Saccharin sodium, Propylene glycol, Sorbitol, Flavor and Purified water.

Dihydrocodeine Bitartrate is an antitussive with the chemical name (Morphinan-6-ol 4, 5α-Epoxy-3-methoxy-17-methylmorphinan-5α, 6α )=2,3=dihydroxybutanedioate (1:1) (salt) an odorless, fine white powder is an opioid analgesic. It has the following structural formula:

C18H23NO3•C4H6O6                                     M. W. 451.47

Brompheniramine Maleate is an antihistamine having the chemical name, 2-Pyridinepropanamine, γ-(4-bromophenyl)-N, N-dimethyl-, (±)-,(Z)-2-butenedicate (1:1), with the following structure:

C16H19BrN2 - C4H4O4                                    M. W. 435.31

Phenylephrine hydrochloride is an orally effective nasal decongestant. Chemically it is (-)-m-Hydroxy-α-[(methylamino) methyl]benzyl alcohol hydrochloride. Its chemical structure is as follows:

C9H13NO2 - HCl                                             M. W. 203.67

EndaCof DH - Clinical Pharmacology

Dihydrocodeine is a semi-synthetic narcotic analgesic related to codeine, with multiple actions qualitatively similar to those of codeine; the most prominent of these involve the central nervous system and organs with smooth muscle components. Brompheniramine Maleate is an alkylamine type antihistamine. This group of antihistamines is among the most active histamine antagonists and is generally effective in relatively low doses. The drugs are not so prone to produce drowsiness and are among the most suitable agents for daytime use, but a significant proportion of patients do experience this effect. Phenylephrine HCl is a sympathomimetic, which acts predominately on alpha-receptors and has little action on beta-receptors. It therefore functions as an oral nasal decongestant with minimal CNS stimulation.

Indications and Usage for EndaCof DH

ENDACOF-DH Oral Liquid is indicated to control cough and provide for temporary relief from congestion associated with the upper respiratory tract.

Contraindications

This combination product is contraindicated in patients with hypersensitivity to Dihydrocodeine, codeine, or any of the active and inactive components listed above, or in any situation where opiods are contraindicated including significant respiratory depression (in unmonitored settings or in the absence of resuscitation equipment), acute or severe bronchial asthma or hypercapnia, and paralytic illeus. Antihistamines and sympathomimetics are contraindicated in patients receiving antihypertensive or antidepressant drugs containing monoamine oxidase (MAO) inhibitors. Antihistamines should not be used to treat lower respiratory tract symptoms or be given to premature or newborn infants Sympathomimetic agents are contraindicated in patients with severe hypertension, severe coronary artery disease, patients with narrow angle glaucoma, bronchial asthma, urinary retention, peptic ulcer, and during an asthma attack. This product is contraindicated in women who are pregnant.

Warnings

General

Considerable caution should be exercised in patients with hypertension, diabetes mellitus, ischemic heart disease, hyperthyroidism, increased intraocular pressure and prostatic hypertrophy. The elderly (60 years and older) are more likely to exhibit adverse reactions. Antihistamines may cause excitability, especially in children. At dosages higher than the recommended dose, nervousness, dizziness, or sleeplessness may occur.

Usage in Ambulatory Patients

Dihydrocodeine may impair the mental and/or physical abilities required for the performance of potentially hazardous takes such as driving a car or operating machinery.

Respiratory Depression

Respiratory depression is the most dangerous acute reaction produced by opiods agonist preparations, although it is rarely severe with usual doses. Oipiods decrease the respiratory rate, tidal volume, minute ventilation, and sensitivity to carbon dioxide. Respiratory depression occurs most frequently in elderly more debilitated patients, usually after large initial doses in non-tolerant patients, or when opiods are given in conjunction with other agents that depress respiration. This combination of products should be used with caution in patients with significant chronic obstructive pulmonary disease or cor pulmonale and in patients with a substantially decreased respiratory reserve, hypoxia hypercapnia, or respiratory depression.

Hypotensive Effect

Dihydrocodeine, like all opioid analgesics, may cause hypotension in patients whose ability to maintain blood pressure has been compromised by a depleted blood volume or who receive concurrent therapy with drugs such as phenothiazines or other agents which compromise vasomotor tone. ENDACOF-DH Oral Liquid may produce orthostatic hypotension in ambulatory patients. This combination product should be administered with caution to patients in circulatory shock, since vacillation produced by the drug may further reduce cardiac output and blood pressure.

Dependence

Dihydrocodeine can produce drug dependence of the codeine type and has the potential of being abused. This product should be prescribed and administered with the appropriate degree of caution. (See Drug Abuse and Dependence section).

Precautions

General

This combination product should be used with caution in elderly or debilitated patients or those with any of the following conditions; adrenocortical insufficiency (e.g., Addison's disease); asthma; central nervous system depression or coma; chronic obstructive pulmonary disease; decreased respiratory reserve (including emphysema, severe obesity, cor pulmonale, or kyphoscoliosis); delirium tremens; diabetes; head injury; hypotension; hypertension; increased intracranial pressure; myxedema or hypothyroidism; prostatic hypertrophy or urethral stricture; and toxic psychosis. The benefits and risks of opiods in patients taking monoamine oxidase inhibitors and in those with a history of drug abuse should be carefully considered. This combination product may aggravate convulsions in patients with convulsive disorders, and, like all opiods, may induce or aggravate seizures in some clinical settings.

Drug Interactions

General

Sympathomimetics may reduce the antihypertensive effects of methyldopa, mecamylamine, reserpine and veratrum alkaloids.

Other Central Nervous System Depressants

Patients receiving other oipioid analgesics, sedatives or hypnotics, muscle relaxants, general anesthetics, centrally acting anti-emetics, phenothiazines or other tranquilizers, or alcohol concomitantly with this combination product may exhibit additive depressant effects on the central nervous system. When such combined therapy is contemplated, the dose of one or both agents should be reduced. Concomitant use of Dihydrocodeine and antihistamines with alcohol and other CNS depressants may have an additive effect.

Monoamine Oxidase Inhibitors

Dihydrocodeine, like all opioids interact with monoamine oxidase inhibitors causing central nervous system excitation and hypertension. MAO inhibitors and beta-adrenergic blockers increase the effects of sympathomimetics. They may also prolong and intensity the anticholinergic effects of antihistamines.

Information for Patient/Caregivers

Patients receiving ENDACOF-DH Oral Liquid should be given the following information:

1. Patients should be advised that ENDACOF-DH Oral Liquid may impair the mental or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery.


2. Patients should be advised to report adverse experiences occurring during therapy.


3. Patients should be advised not to adjust the dose of ENDACOF-DH Oral Liquid without consulting the prescribing professional.


4. Patients should not combine ENDACOF-DH Oral Liquid with alcohol or other central nervous system stimulants.


5. Women of childbearing potential who become, or are planning to become pregnant should be advised to consult their physician regarding the effects of opioids and other drug use during pregnancy on themselves and their unborn child

Patients should be advised that ENDACOF-DH Oral Liquid is a potential drug of abuse. They should protect it from theft, and it should never be given to anyone other than the individual for whom it was prescribed.

Pregnancy

Teratogenic Effects – Pregnancy Category C

Animal reproduction studies have not been conducted with ENDACOF-DH Oral Liquid. It is also not known whether this combination product can cause fetal harm when administered to pregnant women or can affect reproduction capacity in males and females. This combination product should be given to pregnant women only if clearly needed, especially during the first trimester.

Nonteratogenic Effects

Babies born to mothers who have been taking opioids regularly prior to delivery will be physically dependent. The withdrawal signs include irritability and excessive crying, tremors, hyperactive reflexes, increased respiratory rate, increased stools, sneezing, yawning, vomiting and fever. The intensity of the syndrome does not always correlate with the duration of maternal opioid use or dose. There is no consensus on the best method of managing withdrawal. Chlorpromazine 0.7-1.0 mg/kg q6h, Phenobarbital 2 mg/kg q6h, and paregoric 24 drops/kg q4h, have been used to treat withdrawal symptoms in infants. The duration of therapy is 4 to 28 days, with the dosages decreased as tolerated.

Labor and delivery

ENDACOF-DH Oral Liquid is not recommended for use by women during and immediately before labor and delivery because oral opioids may cause respiratory depression in the newborn.

Pediatric Use

This product is not recommended for use in children under 6 years of age. Children under two years may be more susceptible to the respiratory arrest, coma and death. Use of antihistamines is not recommended in infants. This age group may be at a higher risk than other age groups because of an increased susceptibility to anticholinergic effects, such as CNS excitation, and an increased tendency toward convulsions. In older children taking antihistamines, a paradoxical reaction characterized by hyperexcitability may occur. Very young ch8ildren may be more sensitive to the effects, especially the vasopressor effects of sympathomimetic amines.

Geriatric Use

ENDACOF-DH Oral Liquid should be given with caution to the elderly.

Hepatic Impairment

ENDACOF-DH Oral Liquid should be given with caution to patients with hepatic insufficiency. Since dihydrocodeine is metabolized by the liver; the effects of this combination product should be monitored closely in such patients.

Renal Impairment

ENDACOF-DH Oral Liquid should be used with caution and at reduced dosage in the presence of impaired renal function.

Pancreatic/Biliary Tract Disease

Opioids may cause spasms of the sphincter of Oddi and should be sued with caution in patients with biliary tract disease including pancreatitis.

Adverse Reactions

The most frequently observed adverse reactions with dihydrocodeine include light-headedness, dizziness, drowsiness, headache, fatigue, sedation, sweating, nausea, vomiting, constipation, pruritus, and skin reactions. With the exception of constipation, tolerance develops to most of these effects. Other reactions that have been observed with dihydrocodeine or other opioids include respiratory depression, orthostatic hypotension, cough suppression, confusion, diarrhea, miosis, abdominal pain, dry mouth, indigestion, anorexia, spasm of biliary tract, and urinary retention. Physical and psychological dependence are possibilities. Hypersensitivity reactions (including anaphylactoid reactions), hallucinations, vivid dreams, granulomatous interstitial nephritis, sever narcosis and acute renal failure have been reported rarely during dihydrocodeine administration. Other adverse reactions observed with the ingredients in ENDACOF-DH Oral Liquid include, lassitude, nausea, giddiness, dryness of mouth, blurred vision, cardiac palpitations, flushing, increased irritability or excitement (especially in children).

Drug Abuse and Dependence

This combination product is subject to the provisions of the Controlled Substance Act and has been placed in Schedule V. Dihydrocodeine can produce drug dependence of the codeine type and therefore has the potential of being abused. Psychological dependence, physical dependence, and tolerance may develop upon repeated administration of dihydrocodeine, and it should be prescribed and administered with the same degree of caution appropriate to the use of other oral opioid medications. Symptoms of dihydrocodeine withdrawal consist of irritability, restlessness, insomnia, diaphoresis, anxiety and palpitations.

Overdosage

An overdose of ENDACOF-DH Oral Liquid is a potentially lethal poly-drug overdose situation, and consultation with a regional Poison Control Center is recommended. A listing of the poison control centers can be found in standard references such as the Physician's Desk Reference®.

Signs and Symptoms

Symptoms of overdosage include pinpoint pupils, respiratory depression, extreme somnolence progressing to stupor, loss of consciousness, or coma, skeletal muscle, flaccidity, cold and clammy skin and other symptoms common with narcotic overdosage. Convulsions, cardiovascular collapse, and death may occur. A single case of acute rhabdomyolysis associated with an overdose of dihydrocodeine has been reported.

Recommended Treatment

Immediate treatment of an overdosage of ENDACOF-DH Oral Liquid includes support of cardiorespiratory function and measures to reduce drug absorption. Vomiting should be induced with syrup of ipecac, if the patient is alert and has adequate laryngeal reflexes. Oral activated charcoal should follow. The first dose should be accompanied by an appropriate cathartic. Gastric lavage may be necessary. Hypotension is usually hypovolemic and should be treated with fluids. Endotracheal intubation and artificial respiration may be necessary. The pure opioid antagonist naloxone or nalmefene is a specific antidote against respiratory depression that results from opioid overdose. Oipioid antagonists should not be given in the absence of clinically significant respiratory or circulatory depression secondary to opioid overdose. They should be administered cautiously to person who are known, or suspected to be, physically dependent on any opioid agonist including dihydrocodeine. IN such cases, an abrupt or complete reversal of opioid effects may precipitate an acute abstinence syndrome. The prescribing information for the specific opioid antagonist should be consulted for details of their proper use.

DOSAGE AND ADMINISTRATION1

Adults and children 12 years of age and older: 1 teaspoonful every 4 to 6 hours. Not to exceed 6 teaspoonfuls in a 24-hour period.

Children 6 to 12 years of age: 1/2 teaspoonful every 4 to 6 hours. Not to exceed 3 teaspoonfuls in a 24-hour period.

Not recommended for children under 6 years of age.

1

In mild cases or in particularly sensitive patients, less frequent or reduced doses may be appropriate and adequate.

How is EndaCof DH Supplied

A clear colored liquid with a cherry flavor supplied in 16 oz. bottles (NDC 68047-139-16).

Storage

KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN. IN CASE OF ACCIDENTAL OVERDOSE, SEEK PROFESSIONAL ASSISTANCE OR CONTACT A POISON CONTROL CENTER IMMEDIATELY.

Store at 15°-30°C (59°-86°F) [see USP Controlled Room Temperature.] Protect from freezing.

Dispense in a tight, light-resistant container as defined in the USP/NF with a child-resistant closure.

Rx only

Manufactured by:

Deltex Pharmaceuticals, Inc.

Rosenberg, TX 77471

Distributed by:

Larken Laboratories, Inc.

Canton, MS 39046

Rev. 08/09

PRINCIPAL DISPLAY PANEL - 473 mL Bottle Label

NDC 68047-139-16

ENDACOF - DH

Liquid

ANTITUSSIVE / DECONGESTANT / ANTIHISTAMINE

SUGAR FREE ∙ ALCOHOL FREE ∙ DYE FREE

Each teaspoonful (5 mL) contains:

Phenylephrine HCl............... 7.5 mg

Brompheniramine Maleate.... 4 mg

Dihydrocodeine Bitartrate..... 3 mg

*(WARNING-May be habit forming)

Rx Only

LARKEN

LABORATORIES

16 fl. oz. (473 mL)

ENDACOF  DH dihydrocodeine bitartrate, brompheniramine maleate, and phenylephrine hydrochloride  liquid

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 68047-139 Route of Administration ORAL DEA Schedule CV

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Dihydrocodeine Bitartrate (Dihydrocodeine) Dihydrocodeine Bitartrate 3 mg  in 5 mL Brompheniramine Maleate (Brompheniramine) Brompheniramine Maleate 4 mg  in 5 mL Phenylephrine Hydrochloride (Phenylephrine) Phenylephrine Hydrochloride 7.5 mg  in 5 mL

Inactive Ingredients Ingredient Name Strength SODIUM BENZOATE   SACCHARIN SODIUM   PROPYLENE GLYCOL   SORBITOL

Product Characteristics Color      Score      Shape Size Flavor CHERRY Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 68047-139-16 473 mL In 1 BOTTLE, DISPENSING None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
UNAPPROVED DRUG OTHER		09/23/2009

Labeler - Larken Laboratories, Inc. (791043719)

Establishment
Name	Address	ID/FEI	Operations
Larken Laboratories, Inc.		791043719	API MANUFACTURE

Revised: 12/2009Larken Laboratories, Inc.

More EndaCof DH resources

• EndaCof DH Side Effects (in more detail)
• EndaCof DH Dosage
• EndaCof DH Use in Pregnancy & Breastfeeding
• EndaCof DH Drug Interactions
• EndaCof DH Support Group
• 0 Reviews for EndaCof DH - Add your own review/rating

Compare EndaCof DH with other medications

• Cold Symptoms
• Cough and Nasal Congestion

Clindamycin

Pronunciation: KLIN-da-MYE-sin
Generic Name: Clindamycin
Brand Name: Cleocin

Infrequently, there are severe, rarely fatal, intestinal problems that can occur after use of Clindamycin. Consult your doctor right away if you develop persistent diarrhea, stomach pain, or blood or mucus in your stool. These symptoms may occur weeks after stopping use of Clindamycin. Do not use antidiarrhea products or narcotic pain medicines if you have these symptoms. These products may make the symptoms worse. Your doctor will monitor you closely while you are using Clindamycin.

Clindamycin is used for:

Treating serious infections caused by certain bacteria. It is not used to treat meningitis.

Clindamycin is a lincomycin antibiotic. Clindamycin kills sensitive bacteria by stopping the production of essential proteins needed by the bacteria to survive.

Do NOT use Clindamycin if:

• you are allergic to any ingredient in Clindamycin or to lincomycin


• you have certain intestinal problems (eg, antibiotic-associated colitis, Crohn disease, ulcerative colitis) or meningitis

Contact your doctor or health care provider right away if any of these apply to you.

Before using Clindamycin:

Some medical conditions may interact with Clindamycin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have diarrhea, or a history of liver problems or stomach or bowel problems (eg, colitis)


• if you are allergic to tartrazine

Some MEDICINES MAY INTERACT with Clindamycin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Nondepolarizing muscle relaxants (eg, vecuronium) or succinylcholine because the risk of their side effects may be increased by Clindamycin


• Erythromycin because it may decrease Clindamycin's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Clindamycin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Clindamycin:

Use Clindamycin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Clindamycin by mouth with or without food.


• Take Clindamycin with a full glass of water (8 oz/240 mL).


• Clindamycin works best if it is taken at the same time each day.


• To clear up your infection completely, take Clindamycin for the full course of treatment. Keep taking it even if you feel better in a few days.


• If you miss a dose of Clindamycin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Clindamycin.

Important safety information:

• Clindamycin only works against bacteria; it does not treat viral infections (eg, the common cold).


• Be sure to use Clindamycin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.


• Long-term or repeated use of Clindamycin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.


• This product may contain tartrazine dye (FD&C Yellow No. 5). This may cause an allergic reaction in some patients. If you have ever had an allergic reaction to tartrazine, ask your pharmacist if your product has tartrazine in it.


• Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.


• Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Clindamycin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Clindamycin with caution in the ELDERLY; they may be more sensitive to its effects, especially diarrhea.


• Use Clindamycin with extreme caution in CHILDREN younger than 10 years old who have diarrhea or an infection of the stomach or bowel.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Clindamycin while you are pregnant. Clindamycin is found in breast milk. If you are or will be breast-feeding while you use Clindamycin, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Clindamycin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild diarrhea; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or tarry stools; decreased urination; joint pain or swelling; red, swollen, blistered, or peeling skin; severe or persistent diarrhea; severe stomach cramps or pain; unusual vaginal discharge, itching, or odor; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Clindamycin:

Store Clindamycin at room temperature, between 68 to 77 degrees F (20 to 25 degrees C) in a tightly-closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Clindamycin out of the reach of children and away from pets.

General information:

• If you have any questions about Clindamycin, please talk with your doctor, pharmacist, or other health care provider.


• Clindamycin is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Clindamycin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Clindamycin resources

• Clindamycin Dosage
• Clindamycin Use in Pregnancy & Breastfeeding
• Drug Images
• Clindamycin Drug Interactions
• Clindamycin Support Group
• 79 Reviews for Clindamycin - Add your own review/rating

• Clindamycin Professional Patient Advice (Wolters Kluwer)


• clindamycin Oral, Injection, Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information


• clindamycin Concise Consumer Information (Cerner Multum)


• Cleocin Pediatric Prescribing Information (FDA)


• Cleocin Phosphate Prescribing Information (FDA)


• Clindamycin Hydrochloride Monograph (AHFS DI)

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Grenovix

Grenovix may be available in the countries listed below.

Ingredient matches for Grenovix

Ambroxol

Ambroxol hydrochloride (a derivative of Ambroxol) is reported as an ingredient of Grenovix in the following countries:

• Greece

International Drug Name Search

Chromacaps

Generic Name: chromium supplement (Oral route, Parenteral route)

Commonly used brand name(s)

In the U.S.

• Amino-CR


• Chromacaps


• Chromate


• Chromax


• M2 Chromium


• Nia-Chrom

Available Dosage Forms:

• Tablet


• Capsule


• Capsule, Liquid Filled

Uses For Chromacaps

Chromium supplements are used to prevent or treat chromium deficiency.

The body needs chromium for normal growth and health. For patients who are unable to get enough chromium in their regular diet or who have a need for more chromium, chromium supplements may be necessary. They are generally taken by mouth but some patients may have to receive them by injection. Chromium helps your body use sugar properly. It is also needed for the breakdown of proteins and fats.

Lack of chromium may lead to nerve problems and may decrease the body's ability to use sugar properly.

There is not enough evidence to show that taking chromium supplements improves the way your body uses sugar (glucose tolerance).

Injectable chromium is given by or under the supervision of a health care professional. Other forms are available without a prescription.

Importance of Diet

For good health, it is important that you eat a balanced and varied diet. Follow carefully any diet program your health care professional may recommend. For your specific dietary vitamin and/or mineral needs, ask your health care professional for a list of appropriate foods. If you think that you are not getting enough vitamins and/or minerals in your diet, you may choose to take a dietary supplement.

Chromium is found in various foods, including brewer's yeast, calf liver, American cheese, and wheat germ.

The daily amount of chromium needed is defined in several different ways.

• For U.S.—


• Recommended Dietary Allowances (RDAs) are the amount of vitamins and minerals needed to provide for adequate nutrition in most healthy persons. RDAs for a given nutrient may vary depending on a person's age, sex, and physical condition (e.g., pregnancy).


• Daily Values (DVs) are used on food and dietary supplement labels to indicate the percent of the recommended daily amount of each nutrient that a serving provides. DV replaces the previous designation of United States Recommended Daily Allowances (USRDAs).

• For Canada—


• Recommended Nutrient Intakes (RNIs) are used to determine the amounts of vitamins, minerals, and protein needed to provide adequate nutrition and lessen the risk of chronic disease.

Because a lack of chromium is rare, there is no RDA or RNI for it. Normal daily recommended intakes for chromium are generally defined as follows:

• Infants and children—
  
  • Birth to 3 years of age—10 to 80 micrograms (mcg) a day.
  
  
  • 4 to 6 years of age—30 to 120 mcg a day.
  
  
  • 7 to 10 years of age—50 to 200 mcg a day.
  
  


• Adolescents and adults—50 to 200 mcg a day.

Before Using Chromacaps

If you are taking a dietary supplement without a prescription, carefully read and follow any precautions on the label. For these supplements, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Problems in children have not been reported with intake of normal daily recommended amounts.

Geriatric

Problems in older adults have not been reported with intake of normal daily recommended amounts.

Pregnancy

It is especially important that you are receiving enough vitamins and minerals when you become pregnant and that you continue to receive the right amount of vitamins and minerals throughout your pregnancy. The healthy growth and development of the fetus depend on a steady supply of nutrients from the mother. However, taking large amounts of a dietary supplement during pregnancy may be harmful to the mother and/or fetus and should be avoided.

Breast Feeding

It is important that you receive the right amounts of vitamins and minerals so that your baby will also get the vitamins and minerals needed to grow properly. However, taking large amounts of a dietary supplement while breast-feeding may be harmful to the mother and/or baby and should be avoided.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of dietary supplements in this class. Make sure you tell your doctor if you have any other medical problems, especially:

• Type 2 diabetes mellitus—Taking chromium supplements when you have a chromium deficiency may cause a change in the amount of insulin you need.

Proper Use of chromium supplement

This section provides information on the proper use of a number of products that contain chromium supplement. It may not be specific to Chromacaps. Please read with care.

Dosing

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (capsules and tablets):
  
  • To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes:
    
    • Adults and teenagers—50 to 200 micrograms (mcg) per day.
    
    
    • Children 7 to 10 years age—50 to 200 mcg per day.
    
    
    • Children 4 to 6 years of age—30 to 120 mcg per day.
    
    
    • Children birth to 3 years of age—10 to 80 mcg per day.
    
    
  
  
  • To treat deficiency:
    
    • Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss taking chromium supplements for one or more days there is no cause for concern, since it takes some time for your body to become seriously low in chromium. However, if your health care professional has recommended that you take chromium, try to remember to take it as directed every day.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Chromacaps Side Effects

No side effects or overdoses have been reported for chromium. However, check with your health care professional if you notice any unusual effects while you are taking it.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Chromacaps resources

• Chromacaps Side Effects (in more detail)
• Chromacaps Use in Pregnancy & Breastfeeding
• Chromacaps Drug Interactions
• Chromacaps Support Group
• 4 Reviews for Chromacaps - Add your own review/rating

Compare Chromacaps with other medications

• Diabetes, Type 2
• Vitamin/Mineral Supplementation and Deficiency